Hmm this is very odd, I’ve a few questions that might help us to track it down.
How many monitors do you have? Are you running the game windowed or fullscreen (and at what resolution) do you alt-tab at all or switch tasks/windows any other way (i mean if you don’t id be interested if alt-tabbing about brings the mouse back? Is it a traditional mouse?
Also if you could attach the output log for a play session where you have had to alt-f4 that woudl be great too
“your game log file. On Windows, this file is called output_log.txt that can be found in a folder called thesignalfrom_Data, within the game’s folder. (You can share the content of this file using Pastebin9 or similar service and link the result here.)”